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1

Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment

Novotná, Eva, Büküm, Neslihan, Hofman, Jakub, Flaxová, Michaela, Kouklíková, Etela, Louvarová, Dagmar, Wsól, Vladimír

Journal:

Biochemical Pharmacology

Year:

2018

Language:

english

File:

PDF, 1.82 MB

english, 2018

2

Metabolite profile of sibutramine in human urine: a liquid chromatography-electrospray ionization mass spectrometric study

Marek Link, Kati S. Hakala, Vladimír Wsól, Risto Kostiainen, Raimo A. Ketola

Journal:

Journal of Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 194 KB

english, 2006

3

Carbonyl reduction pathways in drug metabolism

Malátková, Petra, Wsól, Vladimír

Journal:

Drug Metabolism Reviews

Year:

2014

Language:

english

File:

PDF, 1.07 MB

english, 2014

4

Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile

Novotná, Eva, Büküm, Neslihan, Hofman, Jakub, Flaxová, Michaela, Kouklíková, Etela, Louvarová, Dagmar, Wsól, Vladimír

Journal:

Archives of Toxicology

Year:

2018

Language:

english

File:

PDF, 1.06 MB

english, 2018

5

Stereoselective pharmacokinetics of flobufen in rats

Frantisek Trejtnar, Vladimir Wsol, Barbora Szotakova, Lenka Skalova, Petr Pavek, Miroslav Kuchar

Journal:

Year:

1999

Language:

english

File:

PDF, 101 KB

english, 1999

6

A comparison between stereospecificity of oracin reduction and stereoselectivity of oxidation of 11-dihydrooracin enantiomers in vitro in rat and guinea pig

Lenka Skálová, Vladimír Wsól, Barbora Szotáková, Eva Kvasničková

Journal:

Year:

1999

Language:

english

File:

PDF, 111 KB

english, 1999

7

Sex differences in stereospecificity of oracin reductases in rat in vitro and in vivo

Vladimír Wsól, Lenka Skálová, Barbora Szotáková, František Trejtnar, Eva Kvasničková

Journal:

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

8

Activity, stereospecificity, and stereoselectivity of microsomal enzymes in dependence on storage and freezing of rat liver samples

Lenka Skálová, Barbora Szotáková, Vladimír Wsól, Radim Král, Vendula Baliharová, Jiří Lamka

Journal:

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

9

ChemInform Abstract: 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: Synthesis and Biological Activity of a Novel Group of Potential Antifungal Drugs.

Milan Pour, Marcel Spulak, Vladimir Buchta, Petra Kubanova, Marie Voprsalova, Vladimir Wsol, Helena Fakova, Petr Koudelka, Hana Pourova, Radan Schiller

Journal:

Year:

2001

File:

PDF, 29 KB

2001

10

Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions

Lenka Skálová, Barbora Szotáková, Jiří Lamka, Radim Král, Ilona Vaňková, Vendula Baliharová, Vladimír Wsól

Journal:

Year:

2001

Language:

english

File:

PDF, 85 KB

english, 2001

11

Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: Phase I of biotransformation

Vladimír Wsól, Radim Král, Lenka Skálová, Barbora Szotáková, František Trejtnar, Miroslav Flieger

Journal:

Year:

2001

Language:

english

File:

PDF, 236 KB

english, 2001

12

Reduction of flobufen in pig hepatocytes: Effect of pig breed (domestic, wild) and castration

Lenka Skálová, Vladimír Wsól, Vendula Baliharová, Radim Král, Barbora Szotáková, Jakub Velík, Jirí Lamka

Journal:

Year:

2003

Language:

english

File:

PDF, 116 KB

english, 2003

13

Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes

Lenka Skálová, Radim Král, Barbora Szotáková, Yogeeta N. Babú, Lydiane Pichard-Garcia, Vladimír Wsól

Journal:

Year:

2003

Language:

english

File:

PDF, 309 KB

english, 2003

14

Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs

František Trejtnar, Radim Král, Petr Pávek, Vladimír Wsól

Journal:

Year:

2003

Language:

english

File:

PDF, 105 KB

english, 2003

15

Stereospecificity of flobufen metabolism in guinea pigs in vitro and in vivo: Phase I of biotransformation

Radim Kral, Lenka Skalova, Barbora Szotakova, Yogeeta N. Babu, Vladimir Wsol

Journal:

Year:

2004

Language:

english

File:

PDF, 121 KB

english, 2004

16

Liquid chromatography–tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes

Bohumila Suchanova, Ludek Sispera, Vladimir Wsol

Journal:

Analytica Chimica Acta

Year:

2006

Language:

english

File:

PDF, 356 KB

english, 2006

17

HPLC—radiometric determination of quinlukast in biological fluids

Matej Syrovatko, Alice Laznickova, Milan Laznicek, Vladimir Wsol

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2004

Language:

english

File:

PDF, 81 KB

english, 2004

18

Aldo-keto reductases (AKR) from the AKR1C subfamily catalyze the carbonyl reduction of the novel anticancer drug oracin in man

Vladimir Wsol, Barbora Szotakova, Hans-Joerg Martin, Edmund Maser

Journal:

Year:

2007

Language:

english

File:

PDF, 410 KB

english, 2007

19

Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin

Lucie Škarydová, Adam Skarka, Romana Novotná, Lucie Živná, Hans-Jörg Martin, Vladimír Wsól, Edmund Maser

Journal:

Year:

2009

Language:

english

File:

PDF, 573 KB

english, 2009

20

Separation of the stereoisomers of the main metabolite of a non-steroidal anti-inflammatory drug, flobufen, by chiral high-performance liquid chromatography

Vladimír Wsól, Anthony F. Fell, Eva Kvasničková, Ivo M. Hais

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1997

Language:

english

File:

PDF, 542 KB

english, 1997

21

The stereospecificity of flobufen metabolism in isolated guinea pig hepatocytes

Radim Kral, Lenka Skalova, Barbora Szotakova, Jakub Velik, Ladislava Schroterova, Yogeeta N Babu, Vladimir Wsol

Journal:

BMC Pharmacology

Year:

2003

Language:

english

File:

PDF, 312 KB

english, 2003

22

Reduction of the Potential Anticancer Drug Oracin in the Rat Liver In-vitro

BARBORA SZOTÁKOVÁ, LENKA SKÁLOVÁ, VLADIMÍR WSÓL, EVA KVASNIÈČKOVÁ

Journal:

Journal of Pharmacy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 75 KB

english, 2000

23

Stereospecific reduction of the original anticancer drug oracin in rat extrahepatic tissues

Barbora Szotáková, Lenka Skálová, Petr Jílek, Vladimír Buchta, Vladimír Wsól

Journal:

Journal of Pharmacy and Pharmacology

Year:

2003

Language:

english

File:

PDF, 193 KB

english, 2003

24

Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes

Barbora Szotáková, Lenka Skálová, Vendula Baliharová, Martina Dvorščaková, Lenka Štorkánová, Luděk Šišpera, Vladimír Wsól

Journal:

Journal of Pharmacy and Pharmacology

Year:

2004

Language:

english

File:

PDF, 291 KB

english, 2004

25

The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes

Marek Link, Romana Novotná, Bohumila Suchanová, Lenka Skálová, Vladimír Wsól, Barbora Szotáková

Journal:

Journal of Pharmacy and Pharmacology

Year:

2005

Language:

english

File:

PDF, 161 KB

english, 2005

26

AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids

Lucie Škarydová, Lucie Živná, Guangming Xiong, Edmund Maser, Vladimír Wsól

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 788 KB

english, 2009

27

Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3

Claudia A. Staab, Tereza Hartmanová, Yasser El-Hawari, Bettina Ebert, Michael Kisiela, Vladimir Wsol, Hans-Jörg Martin, Edmund Maser

Journal:

Chemico-Biological Interactions

Year:

2011

Language:

english

File:

PDF, 1.00 MB

english, 2011

28

Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase

Adam Skarka, Lucie Škarydová, Hana Štambergová, Vladimír Wsól

Journal:

Chemico-Biological Interactions

Year:

2011

Language:

english

File:

PDF, 541 KB

english, 2011

29

Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29

Bettina Ebert, Michael Kisiela, Vladimir Wsól, Edmund Maser

Journal:

Chemico-Biological Interactions

Year:

2011

Language:

english

File:

PDF, 1.32 MB

english, 2011

30

Metabolic pathways of flobufen — a new antirheumatic and antiarthritic drug. Interspecies comparison

Eva Kvasnicková, Barbora Szotáková, Vladimír Wsól, František Trejtnar, Lenka Skálová, Ivo M. Hais, Miroslav Kuchar, Marie Poppová

Journal:

Experimental and Toxicologic Pathology

Year:

1999

Language:

english

File:

PDF, 771 KB

english, 1999

31

Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli

Petra Malátková, Bettina Ebert, Vladimír Wsól, Edmund Maser

Journal:

Biochemical and Biophysical Research Communications

Year:

2012

Language:

english

File:

PDF, 570 KB

english, 2012

32

Liquid chromatographic–electrospray mass spectrometric determination (LC–ESI-MS) of phase II metabolites of flobufen in rat liver microsomes—Chiral discrimination

Yogeeta N. Babú, Michal Němec, Petr Solich, Vladimír Wsól

Journal:

Year:

2008

Language:

english

File:

PDF, 587 KB

english, 2008

33

Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles

Kozic, Ján, Novotná, Eva, Volková, Marie, Stolaříková, Jiřina, Trejtnar, František, Wsól, Vladimír, Vinšová, Jarmila

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 498 KB

english, 2012

34

Inactivation of the anticancer drugs doxorubicin and oracin by aldo–keto reductase (AKR) 1C3

Romana Novotna, Vladimir Wsol, Guangming Xiong, Edmund Maser

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 330 KB

english, 2008

35

Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily

Škarydová, Lucie, Wsól, Vladimír

Journal:

Drug Metabolism Reviews

Year:

2012

Language:

english

File:

PDF, 989 KB

english, 2012

36

3-Phenyl-5-acyloxymethyl-2 H , 5H -furan-2-ones: Synthesis and Biological Activity of a Novel Group of Potential Antifungal Drugs †

Pour, Milan, Špulák, Marcel, Buchta, Vladimír, Kubanová, Petra, Vopršalová, Marie, Wsól, Vladimír, Fáková, Helena, Koudelka, Petr, Pourová, Hana, Schiller, Radan

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

37

S-Nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity

Hartmanová, Tereza, Tambor, Vojtěch, Lenčo, Juraj, Staab-Weijnitz, Claudia A., Maser, Edmund, Wsól, Vladimír

Journal:

Chemico-Biological Interactions

Year:

2013

Language:

english

File:

PDF, 870 KB

english, 2013

38

Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors

Skarydova, Lucie, Hofman, Jakub, Chlebek, Jakub, Havrankova, Jana, Kosanova, Katerina, Skarka, Adam, Hostalkova, Anna, Plucha, Tomas, Cahlikova, Lucie, Wsol, Vladimir

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2014

Language:

english

File:

PDF, 885 KB

english, 2014

39

Anthracycline resistance mediated by reductive metabolism in cancer cells: The role of aldo-keto reductase 1C3

Hofman, Jakub, Malcekova, Beata, Skarka, Adam, Novotna, Eva, Wsol, Vladimir

Journal:

Toxicology and Applied Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.80 MB

english, 2014

40

Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells

Skarka, Adam, Škarydová, Lucie, Štambergová, Hana, Wsól, Vladimír

Journal:

Protein Expression and Purification

Year:

2014

Language:

english

File:

PDF, 710 KB

english, 2014

41

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7

Stambergova, Hana, Skarydova, Lucie, Dunford, James E., Wsol, Vladimir

Journal:

Chemico-Biological Interactions

Year:

2014

Language:

english

File:

PDF, 888 KB

english, 2014

42

Synthesis and Biological Activity of Quaternary Ammonium Salt-Type Agents Containing Cholesterol and Terpenes

Novotná, Eva, Waisser, Karel, Kuneš, Jiří, Palát, Karel, Buchta, Vladimír, Stolaříková, Jiřina, Beckert, Rainer, Wsól, Vladimír

Journal:

Archiv der Pharmazie

Year:

2014

Language:

english

File:

PDF, 193 KB

english, 2014

43

Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase

Krátký, Martin, Vinšová, Jarmila, Novotná, Eva, Mandíková, Jana, Wsól, Vladimír, Trejtnar, František, Ulmann, Vít, Stolaříková, Jiřina, Fernandes, Steve, Bhat, Shridhar, Liu, Jun O.

Journal:

Year:

2012

Language:

english

File:

PDF, 255 KB

english, 2012

44

Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3)

Lundová, Tereza, Zemanová, Lucie, Malčeková, Beata, Skarka, Adam, Štambergová, Hana, Havránková, Jana, Šafr, Miroslav, Wsól, Vladimír

Journal:

Chemico-Biological Interactions

Year:

2015

Language:

english

File:

PDF, 2.31 MB

english, 2015

45

Efficient isolation of carbonyl-reducing enzymes using affinity approach with anticancer drug oracin as a specific ligand

Škarydová, Lucie, Andrýs, Rudolf, Holubová, Lucie, Štambergová, Hana, Kňavová, Jana, Wsól, Vladimír, Bílková, Zuzana

Journal:

Journal of Separation Science

Year:

2013

Language:

english

File:

PDF, 380 KB

english, 2013

46

In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

Killi, Uday K, Wsol, Vladimir, Soukup, Ondrej, Kuca, Kamil, Winder, Michael, Tobin, Gunnar

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2014

Language:

english

File:

PDF, 334 KB

english, 2014

47

Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetone in vitro

Skarydova, Lucie, Nobilis, Milan, Wsól, Vladimir

Journal:

Year:

2013

Language:

english

File:

PDF, 828 KB

english, 2013

48

Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier

Andrýs, Rudolf, Zemanová, Lucie, Lenčo, Juraj, Bílková, Zuzana, Wsól, Vladimír

Journal:

Chemico-Biological Interactions

Year:

2015

Language:

english

File:

PDF, 1.47 MB

english, 2015

49

The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man

Malátková, Petra, Havlíková, Lucie, Wsól, Vladimír

Journal:

Chemico-Biological Interactions

Year:

2014

Language:

english

File:

PDF, 974 KB

english, 2014

50

Inhibition of Nitric Oxide Synthase Prevents Muscarinic and Purinergic Functional Changes and Development of Cyclophosphamide-Induced Cystitis in the Rat

Aronsson, Patrik, Vesela, Renata, Johnsson, Martin, Tayem, Yasin, Wsol, Vladimir, Winder, Michael, Tobin, Gunnar

Journal:

BioMed Research International

Year:

2014

Language:

english

File:

PDF, 2.11 MB

english, 2014